Cellular immune response to Mycobacterium tuberculosis -specific antigen culture filtrate protein-10 in south India
Identifieur interne : 002911 ( Main/Exploration ); précédent : 002910; suivant : 002912Cellular immune response to Mycobacterium tuberculosis -specific antigen culture filtrate protein-10 in south India
Auteurs : Madhan Kumar [Inde] ; Jagadish C. Sundaramurthi [Inde] ; Narinder K. Mehra [Inde] ; Gurvinder Kaur [Inde] ; Alamelu Raja [Inde]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 2010-02-01.
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Abstract
Abstract: The Mycobacterium tuberculosis (M. tuberculosis)-specific culture filtrate protein-10 (CFP-10) is highly recognized by M. tuberculosis infected subjects. In the present study, the proliferative response and IFN-γ secretion was found for C-terminal peptides of the protein (Cfp651–70, Cfp761–80, Cfp871–90, and Cfp981–100). The alleles HLA DRB1 *04 and HLA DRB1 *10 recognized the C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6 was predominantly recognized by the alleles HLA DRB1 *03 and HLA DRB1 *15 by PTB. The minimal nonameric epitopes from the C-terminal region were CFP-1056–64 and CFP-1076–84. These two peptides deserve attention for inclusion in a vaccine against tuberculosis in this region.
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DOI: 10.1007/s00430-009-0129-2
Affiliations:
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